Headspace Oven Automates Water Separation from Difficult Samples Prior to Titration


Titration is one of the oldest methods for content determination in chemistry, commonly used to ascertain an unknown component within a solution. This is achieved by monitoring the final reaction of a quantified reagent that has been introduced to the sample, using an indicator such as colour or pH.

Traditionally, titration, or volumetry as it is also known, is performed quickly and economically using basic laboratory apparatus such as a beaker, stirrer, glass burette and maybe a simple pH meter. The actual test itself is not time consuming but when you consider the importance of measurement uncertainty and traceability and compare it to the overall time of an automated experiment, the advantages of the latest technologies on offer become obvious. 

Instruments such as Xylem's TitroLine® 7800 with IDS technology can help take away the pain and potential errors caused by human interpretation of manual titration end points and subsequent empirical calculations. They can also provide data security and an audit trail thanks to innovative digital signal handling and sensor recognition – ideal for applications requiring compliance with FDA regulation 21 CR Part 11. (Read more about how Xylem products can help you comply to FDA regulation 21 CFR Part 11 here.)

Advantages of the headspace oven and the sample changer: 

  • Semi automatic or fully automatic water determination
  • No contamination of the anolyte, generator and indicator electrodes
  • Application range from 35-280°C 

Xylem brand SI Analytics’ latest TitroLine® KF solution for semi or fully automated titration of water in liquids, solids and even pastes using the new TO 7280 headspace oven not only automates the measurement process but handles sample preparation too. This provides for a faster throughput of samples, more reliable results, reduced costs and also offers the benefit of a safer experiment by removing the need to handle solvents, analytes and specialty gases.

The headspace oven technique is suitable for the following samples: 

  • Pharmaceutical products
  • Natural products
  • Plastics
  • Hygroscopic substances
  • Freeze-dried products, e.g. lyophilisates
  • Oils and lubricants, creams, pastes
  • Viscous materials (bitumen, tar, sewage sludge)
  • Powder and pellets
  • Food
  • Petrochemicals

To learn more about the theory of pH measurement, titration or conductivity please contact us today and ask for one of our handbooks, or take a look around our website. 

Click the link to download our latest brochure “Water determination in all types of samples” and learn more about the new Headspace Oven and Sample Changer for coulometric KF titration.

  Water determination in all types of samples